Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus

BACKGROUND: Independent genome-wide association studies (GWAS) showed an obesogenic effect of two single nucleotide polymorphisms (SNP; rs12970134 and rs17782313) more than 150 kb downstream of the melanocortin 4 receptor gene (MC4R). It is unclear if the SNPs directly influence MC4R function or exp...

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Main Authors: Scherag, André, Jarick, Ivonne, Grothe, Jessica, Biebermann, Heike, Scherag, Susann, Volckmar, Anna-Lena, Vogel, Carla Ivane Ganz, Greene, Brandon, Hebebrand, Johannes, Hinney, Anke
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981522/
https://ncbi.nlm.nih.gov/pubmed/21085626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013967
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