Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin

Granulysin (GNLY), an antimicrobial protein present in the granules of human cytotoxic T lymphocytes and natural killer (NK) cells, is produced as an intact 15-kDa form that is cleaved to yield a 9-kDa form. Alarmins are endogenous mediators that can induce recruitment and activation of antigen-pres...

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Detalhes bibliográficos
Main Authors: Tewary, Poonam, Yang, De, de la Rosa, Gonzalo, Li, Yana, Finn, Michael W., Krensky, Alan M., Clayberger, Carol, Oppenheim, Joost J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981473/
https://ncbi.nlm.nih.gov/pubmed/20660289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-273953
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