Differentiation between Polymorphisms and Resistance-Associated Mutations in Human Cytomegalovirus DNA Polymerase

Specific mutations in the human cytomegalovirus (HCMV) DNA polymerase (pUL54) are known to confer resistance against all currently licensed drugs for treatment of HCMV infection and disease. Following the widespread use of antivirals, the occurrence of HCMV drug resistance is constantly increasing....

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Bibliographic Details
Main Authors: Chevillotte, Meike, Ersing, Ina, Mertens, Thomas, von Einem, Jens
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981283/
https://ncbi.nlm.nih.gov/pubmed/20876378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00259-10
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