A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro

A doxorubicin derivate, SA-17, that carries a squaric acid amide ester moiety at the carbohydrate (α-l-daunosaminyl) group was identified as a selective inhibitor of in vitro dengue virus (DENV) serotype 2 replication (50% effective concentration [EC(50)] = 0.34 ± 0.20 μg/ml [0.52 ± 0.31 μM]). SA-17...

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Detalhes bibliográficos
Main Authors: Kaptein, Suzanne J. F., De Burghgraeve, Tine, Froeyen, Mathy, Pastorino, Boris, Alen, Marijke M. F., Mondotte, Juan A., Herdewijn, Piet, Jacobs, Michael, de Lamballerie, Xavier, Schols, Dominique, Gamarnik, Andrea V., Sztaricskai, Ferenc, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981273/
https://ncbi.nlm.nih.gov/pubmed/20837762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00686-10
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