Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption(1)(2)(3)(4)

Background: Recently, a genetic variant (rs738409; C→G) of the PNPLA3 gene was identified to be associated with increased hepatic fat deposition, and the effect was more pronounced in Hispanics. Animal models have also shown that PNPLA3 expression can be regulated by dietary carbohydrate. Objective:...

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Bibliographic Details
Main Authors: Davis, Jaimie N, Lê, Kim-Anne, Walker, Ryan W, Vikman, Susanna, Spruijt-Metz, Donna, Weigensberg, Marc J, Allayee, Hooman, Goran, Michael I
Format: Artigo
Language:Inglês
Published: American Society for Nutrition 2010
Subjects:
Gene-Nutrient Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980971/
https://ncbi.nlm.nih.gov/pubmed/20962157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.2010.30185
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