Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption(1)(2)(3)(4)

Background: Recently, a genetic variant (rs738409; C→G) of the PNPLA3 gene was identified to be associated with increased hepatic fat deposition, and the effect was more pronounced in Hispanics. Animal models have also shown that PNPLA3 expression can be regulated by dietary carbohydrate. Objective:...

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Détails bibliographiques
Auteurs principaux: Davis, Jaimie N, Lê, Kim-Anne, Walker, Ryan W, Vikman, Susanna, Spruijt-Metz, Donna, Weigensberg, Marc J, Allayee, Hooman, Goran, Michael I
Format: Artigo
Langue:Inglês
Publié: American Society for Nutrition 2010
Sujets:
Gene-Nutrient Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980971/
https://ncbi.nlm.nih.gov/pubmed/20962157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.2010.30185
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