Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery

OBJECTIVE: To identify inhibitors of the essential chromosome partitioning protein ParA that are active against Mycobacterium tuberculosis. METHODS: Antisense expression of the parA orthologue MSMEG_6939 was induced on the Mycobacterium smegmatis background. Screening of synthetic chemical libraries...

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Main Authors: Nisa, Shahista, Blokpoel, Marian C. J., Robertson, Brian D., Tyndall, Joel D. A., Lun, Shichun, Bishai, William R., O'Toole, Ronan
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980951/
https://ncbi.nlm.nih.gov/pubmed/20810423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq311
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