Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation

Chronic infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric adenocarcinoma. The cagA gene product CagA is injected into gastric epithelial cells and disturbs cellular functions by physically interacting with and deregulating a variety of cellu...

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Main Authors: Tsang, YH, Lamb, A, Romero-Gallo, J, Huang, B, Ito, K, Peek, RM, Ito, Y, Chen, LF
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980823/
https://ncbi.nlm.nih.gov/pubmed/20676134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.304
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