Loading...

Discovery of Entry Inhibitors for HIV-1 via a New De Novo Protein Design Framework

A new (to our knowledge) de novo design framework with a ranking metric based on approximate binding affinity calculations is introduced and applied to the discovery of what we believe are novel HIV-1 entry inhibitors. The framework consists of two stages: a sequence selection stage and a validation...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Bellows, M.L., Taylor, M.S., Cole, P.A., Shen, L., Siliciano, R.F., Fung, H.K., Floudas, C.A.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980751/
https://ncbi.nlm.nih.gov/pubmed/21081094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.050
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!