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Sequence Environment of Mutation Affects Stability and Folding in Collagen Model Peptides of Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI), a disorder characterized by fragile bones, is often a consequence of missense mutations in type I collagen which change one Gly in the repeating (Gly-Xaaa-Yaa)n sequence to a larger amino acid. The impact of local environment and the identity of the residue replacing Gl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2980582/ https://ncbi.nlm.nih.gov/pubmed/20235194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21432 |
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