Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome

Although complement activation is known to occur in the setting of severe hemorrhagic shock and tissue trauma (HS/T), the extent to which complement drives the initial inflammatory response and end-organ damage is uncertain. In this study, complement factor 3-deficient (C3(−/−)) mice and wild-type c...

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Main Authors: Cai, Changchun, Gill, Roop, Eum, Hyun-Ae, Cao, Zongxian, Loughran, Patricia A., Darwiche, Sophie, Edmonds, Rebecca D., Menzel, Christoph L., Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980448/
https://ncbi.nlm.nih.gov/pubmed/20702808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00282.2010
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