p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway

p66Shc, a promoter of apoptosis, modulates oxidative stress response and cellular survival, but its role in the progression of diabetic nephropathy is relatively unknown. In this study, mechanisms by which p66Shc modulates high-glucose (HG)- or angiotensin (ANG) II-induced mitochondrial dysfunction...

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Detalhes bibliográficos
Main Authors: Sun, Lin, Xiao, Li, Nie, Jing, Liu, Fu-you, Ling, Guang-hui, Zhu, Xue-jing, Tang, Wen-bin, Chen, Wen-cui, Xia, Yun-cheng, Zhan, Ming, Ma, Ming-ming, Peng, You-ming, Liu, Hong, Liu, Ying-hong, Kanwar, Yashpal S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980400/
https://ncbi.nlm.nih.gov/pubmed/20739391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00414.2010
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