Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle

The contractile state of vascular smooth muscle cells is regulated by small changes in membrane potential that gate voltage-dependent calcium channels. The melastatin transient receptor potential (TRP) channel TRPM4 is a critical mediator of pressure-induced membrane depolarization and arterial cons...

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Bibliographic Details
Main Authors: Gonzales, Albert L., Garcia, Zarine I., Amberg, Gregory C., Earley, Scott
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
Subjects:
Membrane Transporters, Ion Channels and Pumps
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980315/
https://ncbi.nlm.nih.gov/pubmed/20826763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00269.2010
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