Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

Molecular mechanisms responsible for the clinical progression of chronic myelocytic leukemia to its accelerated phase or to blast crisis have not been defined. We found alterations of the p53 gene (p53 is a 53-kDa nuclear protein) including deletions and rearrangements in 8 of 34 patients in blast c...

Volledige beschrijving

Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Ahuja, H, Bar-Eli, M, Advani, S H, Benchimol, S, Cline, M J
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1989
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2771957/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6783
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!