Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

Molecular mechanisms responsible for the clinical progression of chronic myelocytic leukemia to its accelerated phase or to blast crisis have not been defined. We found alterations of the p53 gene (p53 is a 53-kDa nuclear protein) including deletions and rearrangements in 8 of 34 patients in blast c...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ahuja, H, Bar-Eli, M, Advani, S H, Benchimol, S, Cline, M J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2771957/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6783
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