K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells.

Acidification of the cytoplasm of Ehrlich ascites carcinoma cells to pH 6.3 arrests DNA synthesis in these cells. Such an effect can be achieved by incubating the cells at pH 6.2 or by adding low concentrations of the K+/H+ antiporter, the antibiotic nigericin, at neutral pH. Glucose and anaerobiosi...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Margolis, L B, Novikova I, Y u, Rozovskaya, I A, Skulachev, V P
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297897/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2771947/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6626
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