K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells.

Acidification of the cytoplasm of Ehrlich ascites carcinoma cells to pH 6.3 arrests DNA synthesis in these cells. Such an effect can be achieved by incubating the cells at pH 6.2 or by adding low concentrations of the K+/H+ antiporter, the antibiotic nigericin, at neutral pH. Glucose and anaerobiosi...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Margolis, L B, Novikova I, Y u, Rozovskaya, I A, Skulachev, V P
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1989
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297897/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2771947/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6626
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