The noncovalent complex between DNA and the bifunctional intercalator ditercalinium is a substrate for the UvrABC endonuclease of Escherichia coli.

We have demonstrated that the noncovalent complex formed between DNA and an antitumor bifunctional intercalator, ditercalinium, is recognized in vitro as bulky covalent DNA lesions by the purified Escherichia coli UvrABC endonuclease. It was established that no covalent drug-DNA adduct was formed du...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Lambert, B, Jones, B K, Roques, B P, Le Pecq, J B, Yeung, A T
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297883/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2671994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6557
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