Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART

Although HAART suppresses HIV replication, it is often unable to restore immune homeostasis. Consequently, non-AIDS-defining diseases are increasingly seen in treated individuals. This is attributed to persistent virus expression in reservoirs and to cell activation. Of note, in CD4(+) T cells and m...

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Main Authors: Ensoli, Barbara, Bellino, Stefania, Tripiciano, Antonella, Longo, Olimpia, Francavilla, Vittorio, Marcotullio, Simone, Cafaro, Aurelio, Picconi, Orietta, Paniccia, Giovanni, Scoglio, Arianna, Arancio, Angela, Ariola, Cristina, Ruiz Alvarez, Maria J., Campagna, Massimo, Scaramuzzi, Donato, Iori, Cristina, Esposito, Roberto, Mussini, Cristina, Ghinelli, Florio, Sighinolfi, Laura, Palamara, Guido, Latini, Alessandra, Angarano, Gioacchino, Ladisa, Nicoletta, Soscia, Fabrizio, Mercurio, Vito S., Lazzarin, Adriano, Tambussi, Giuseppe, Visintini, Raffaele, Mazzotta, Francesco, Di Pietro, Massimo, Galli, Massimo, Rusconi, Stefano, Carosi, Giampiero, Torti, Carlo, Di Perri, Giovanni, Bonora, Stefano, Ensoli, Fabrizio, Garaci, Enrico
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978690/
https://ncbi.nlm.nih.gov/pubmed/21085635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013540
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