Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART

Although HAART suppresses HIV replication, it is often unable to restore immune homeostasis. Consequently, non-AIDS-defining diseases are increasingly seen in treated individuals. This is attributed to persistent virus expression in reservoirs and to cell activation. Of note, in CD4(+) T cells and m...

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Autors principals: Ensoli, Barbara, Bellino, Stefania, Tripiciano, Antonella, Longo, Olimpia, Francavilla, Vittorio, Marcotullio, Simone, Cafaro, Aurelio, Picconi, Orietta, Paniccia, Giovanni, Scoglio, Arianna, Arancio, Angela, Ariola, Cristina, Ruiz Alvarez, Maria J., Campagna, Massimo, Scaramuzzi, Donato, Iori, Cristina, Esposito, Roberto, Mussini, Cristina, Ghinelli, Florio, Sighinolfi, Laura, Palamara, Guido, Latini, Alessandra, Angarano, Gioacchino, Ladisa, Nicoletta, Soscia, Fabrizio, Mercurio, Vito S., Lazzarin, Adriano, Tambussi, Giuseppe, Visintini, Raffaele, Mazzotta, Francesco, Di Pietro, Massimo, Galli, Massimo, Rusconi, Stefano, Carosi, Giampiero, Torti, Carlo, Di Perri, Giovanni, Bonora, Stefano, Ensoli, Fabrizio, Garaci, Enrico
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978690/
https://ncbi.nlm.nih.gov/pubmed/21085635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013540
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