Folic Acid Remodels Chromatin on Hes1 and Neurog2 Promoters during Caudal Neural Tube Development

The mechanism(s) behind folate rescue of neural tube closure are not well understood. In this study we show that maternal intake of folate prior to conception reverses the proliferation potential of neural crest stem cells in homozygous Splotch embryos (Sp(−/−)) via epigenetic mechanisms. It is also...

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Detalhes bibliográficos
Main Authors: Ichi, Shunsuke, Costa, Fabricio F., Bischof, Jared M., Nakazaki, Hiromichi, Shen, Yueh-Wei, Boshnjaku, Vanda, Sharma, Saurabh, Mania-Farnell, Barbara, McLone, David G., Tomita, Tadanori, Soares, Marcelo B., Mayanil, Chandra S. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978621/
https://ncbi.nlm.nih.gov/pubmed/20833714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126714
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