Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B

Crystallographic and biochemical studies have been employed to identify the binding site and mechanism for potentiation of imidazoline binding in human monoamine oxidase B (MAO B). 2-(2-Benzofuranyl)-2-imidazoline (2-BFI) inhibits recombinant human MAO B with a K(i) of 8.3 ± 0.6 μm, whereas tranylcy...

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Hauptverfasser: Bonivento, Daniele, Milczek, Erika M., McDonald, G. Reid, Binda, Claudia, Holt, Andrew, Edmondson, Dale E., Mattevi, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978614/
https://ncbi.nlm.nih.gov/pubmed/20855894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169482
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