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Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B
Crystallographic and biochemical studies have been employed to identify the binding site and mechanism for potentiation of imidazoline binding in human monoamine oxidase B (MAO B). 2-(2-Benzofuranyl)-2-imidazoline (2-BFI) inhibits recombinant human MAO B with a K(i) of 8.3 ± 0.6 μm, whereas tranylcy...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978614/ https://ncbi.nlm.nih.gov/pubmed/20855894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169482 |
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