Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion

Dysregulation of microRNAs is observed in many cancers, including breast cancer. In particular, miR-10b appears to play an important role in tumor cell invasion and breast cancer progression. In this study, we investigated hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with c-Src k...

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Bibliografski detalji
Glavni autori: Bourguignon, Lilly Y. W., Wong, Gabriel, Earle, Christine, Krueger, Katherine, Spevak, Christina C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Signal Transduction
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978601/
https://ncbi.nlm.nih.gov/pubmed/20843787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162305
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