Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis

SENP1 (SUMO-specific protease 1) has been shown to be essential for the stability and activity of hypoxia-inducible factor 1 (HIF-1α) under hypoxia conditions. However, it is unknown how SENP1 activation and hypoxia signaling are coordinated in the cellular response to hypoxia. Here, we report the e...

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Bibliographic Details
Main Authors: Xu, Ying, Zuo, Yong, Zhang, Haizeng, Kang, Xunlei, Yue, Fei, Yi, Zhengfang, Liu, Mingyao, Yeh, Edward T. H., Chen, Guoqiang, Cheng, Jinke
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978597/
https://ncbi.nlm.nih.gov/pubmed/20841360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164236
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