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Age-related development of a heterozygous phenotype in solitary neurons of the homozygous Brattleboro rat.

A single-base deletion in the single-copy vasopressin gene is the cause of diabetes insipidus in the homozygous Brattleboro rat (di/di). It results in the synthesis of an altered vasopressin precursor of which the axonal transport is blocked. Paradoxically, a small number of solitary hypothalamic ne...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: van Leeuwen, F, van der Beek, E, Seger, M, Burbach, P, Ivell, R
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1989
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297851/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2762332/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.16.6417
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