Age-related development of a heterozygous phenotype in solitary neurons of the homozygous Brattleboro rat.
A single-base deletion in the single-copy vasopressin gene is the cause of diabetes insipidus in the homozygous Brattleboro rat (di/di). It results in the synthesis of an altered vasopressin precursor of which the axonal transport is blocked. Paradoxically, a small number of solitary hypothalamic ne...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1989
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297851/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2762332/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.16.6417 |
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