Double-stranded DNA-templated cleavage of oligonucleotides containing a P3′→N5′ linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity

We recently reported double-stranded DNA-templated cleavage of oligonucleotides as a sequence-specific DNA-detecting method. In this method, triplex-forming oligonucleotides (TFOs) modified with 5′-amino-2′,4′-BNA were used as a DNA-detecting probe. This modification introduced a P3′→N5′ linkage (P–...

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Detalhes bibliográficos
Main Authors: Ito, Kosuke Ramon, Kodama, Tetsuya, Tomizu, Masaharu, Negoro, Yoshinori, Orita, Ayako, Osaki, Tomohisa, Hosoki, Noritsugu, Tanaka, Takaya, Imanishi, Takeshi, Obika, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Synthetic Biology and Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978371/
https://ncbi.nlm.nih.gov/pubmed/20615902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq600
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