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Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
Aromatic interactions are well-known players in molecular recognition but their catalytic role in biological systems is less documented. Here, we report that a conserved aromatic stacking interaction between dUTPase and its nucleotide substrate largely contributes to the stabilization of the associa...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978360/ https://ncbi.nlm.nih.gov/pubmed/20601405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq584 |
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