DNA synapsis through transient tetramerization triggers cleavage by Ecl18kI restriction enzyme

To cut DNA at their target sites, restriction enzymes assemble into different oligomeric structures. The Ecl18kI endonuclease in the crystal is arranged as a tetramer made of two dimers each bound to a DNA copy. However, free in solution Ecl18kI is a dimer. To find out whether the Ecl18kI dimer or t...

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Main Authors: Zaremba, Mindaugas, Owsicka, Amelia, Tamulaitis, Gintautas, Sasnauskas, Giedrius, Shlyakhtenko, Luda S., Lushnikov, Alexander Y., Lyubchenko, Yuri L., Laurens, Niels, van den Broek, Bram, Wuite, Gijs J. L., Siksnys, Virginijus
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978343/
https://ncbi.nlm.nih.gov/pubmed/20571089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq560
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