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Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.

The nitrogen mustard derivatives of 4-phenylbutyric acid and L-phenylalanine, called chlorambucil (Chl) and melphalan (Mel), respectively, have been incorporated into several peptide hormones, including luteinizing hormone-releasing hormone (LH-RH). The alkylating analogues of LH-RH were prepared by...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bajusz, S, Janaky, T, Csernus, V J, Bokser, L, Fekete, M, Srkalovic, G, Redding, T W, Schally, A V
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297830/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2548207/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.16.6318
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