Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption

BACKGROUND: Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7. To shed light on the intracellular signalling controlling extracellular acidific...

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Autores principales: Sørensen, Mette G, Karsdal, Morten A, Dziegiel, Morten H, Boutin, Jean A, Nosjean, Olivier, Henriksen, Kim
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978137/
https://ncbi.nlm.nih.gov/pubmed/20977756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-11-250
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