Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption

Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibit...

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Detalhes bibliográficos
Main Authors: Karsdal, Morten A., Henriksen, Kim, Sørensen, Mette G., Gram, Jeppe, Schaller, Sophie, Dziegiel, Morten H., Heegaard, Anne-Marie, Christophersen, Palle, Martin, Thomas J., Christiansen, Claus, Bollerslev, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2005
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602325/
https://ncbi.nlm.nih.gov/pubmed/15681830
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