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Phenotypic Complexity, Measurement Bias, and Poor Phenotypic Resolution Contribute to the Missing Heritability Problem in Genetic Association Studies

BACKGROUND: The variance explained by genetic variants as identified in (genome-wide) genetic association studies is typically small compared to family-based heritability estimates. Explanations of this ‘missing heritability’ have been mainly genetic, such as genetic heterogeneity and complex (epi-)...

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Main Authors: van der Sluis, Sophie, Verhage, Matthijs, Posthuma, Danielle, Dolan, Conor V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978099/
https://ncbi.nlm.nih.gov/pubmed/21085666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013929
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