Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2

Erythropoiesis requires erythropoietin (Epo) and stem cell factor (SCF) signaling via their receptors EpoR and c-Kit. EpoR, like many other receptors involved in hematopoiesis, acts via the kinase Jak2. Deletion of EpoR or Janus kinase 2 (Jak2) causes embryonic lethality as a result of defective ery...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Grebien, Florian, Kerenyi, Marc A., Kovacic, Boris, Kolbe, Thomas, Becker, Verena, Dolznig, Helmut, Pfeffer, Klaus, Klingmüller, Ursula, Müller, Mathias, Beug, Hartmut, Müllner, Ernst W., Moriggl, Richard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976848/
https://ncbi.nlm.nih.gov/pubmed/18239084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-102848
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