Idiopathic Male Infertility Is Strongly Associated with Aberrant Promoter Methylation of Methylenetetrahydrofolate Reductase (MTHFR)

BACKGROUND: Abnormal germline DNA methylation in males has been proposed as a possible mechanism compromising spermatogenesis of some men currently diagnosed with idiopathic infertility. Previous studies have been focused on imprinted genes with DNA methylation in poor quality human sperms. However,...

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Main Authors: Wu, Wei, Shen, Ouxi, Qin, Yufeng, Niu, Xiaobing, Lu, Chuncheng, Xia, Yankai, Song, Ling, Wang, Shoulin, Wang, Xinru
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976703/
https://ncbi.nlm.nih.gov/pubmed/21085488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013884
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