Difluorothromboxane A2 and stereoisomers: stable derivatives of thromboxane A2 with differential effects on platelets and blood vessels.

The present study reports on the selective effects on human platelets and canine saphenous veins of four stable difluorinated analogues and thromboxane A2 (TXA2), in which the characteristic 2,6-dioxa[3.1.1]bicycloheptane structure of TXA2 has been retained. The four compounds differ in their stereo...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Morinelli, T A, Okwu, A K, Mais, D E, Halushka, P V, John, V, Chen, C K, Fried, J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297670/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2748606/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.14.5600
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