Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

A family of A + T-rich sequences termed MARs ("matrix association regions") mediate chromosomal loop attachment. Here we demonstrate that several MARs both specifically bind and contain multiple sites of cleavage by topoisomerase II, a major protein of the mitotic chromosomal scaffold. Int...

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Hlavní autoři: Sperry, A O, Blasquez, V C, Garrard, W T
Médium: Artigo
Jazyk:Inglês
Vydáno: 1989
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC297650/
https://ncbi.nlm.nih.gov/pubmed/2546156
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