Calcium Flux between the Endoplasmic Reticulum and Mitochondrion Contributes to Poliovirus-Induced Apoptosis

We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca(2+)) concentration in neuroblastoma IMR5 cells, at least partly through Ca(2+) release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP(3)R) and ryanodine receptor (RyR) channels....

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Main Authors: Brisac, Cynthia, Téoulé, François, Autret, Arnaud, Pelletier, Isabelle, Colbère-Garapin, Florence, Brenner, Catherine, Lemaire, Christophe, Blondel, Bruno
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976416/
https://ncbi.nlm.nih.gov/pubmed/20861253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00994-10
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