Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins

Epac1 is a guanine nucleotide exchange factor for the small G protein Rap and is involved in membrane-localized processes such as integrin-mediated cell adhesion and cell-cell junction formation. Cyclic AMP (cAMP) directly activates Epac1 by release of autoinhibition and in addition induces its tran...

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Autors principals: Gloerich, Martijn, Ponsioen, Bas, Vliem, Marjolein J., Zhang, Zhongchun, Zhao, Jun, Kooistra, Matthijs R., Price, Leo S., Ritsma, Laila, Zwartkruis, Fried J., Rehmann, Holger, Jalink, Kees, Bos, Johannes L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976368/
https://ncbi.nlm.nih.gov/pubmed/20855527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00463-10
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