Nonlinear Biosynthetic Gene Cluster Dose Effect on Penicillin Production by Penicillium chrysogenum

Industrial penicillin production levels by the filamentous fungus Penicillium chrysogenum increased dramatically by classical strain improvement. High-yielding strains contain multiple copies of the penicillin biosynthetic gene cluster that encodes three key enzymes of the β-lactam biosynthetic path...

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Main Authors: Nijland, Jeroen G., Ebbendorf, Bjorg, Woszczynska, Marta, Boer, Rémon, Bovenberg, Roel A. L., Driessen, Arnold J. M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
主題:
Biotechnology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976272/
https://ncbi.nlm.nih.gov/pubmed/20851974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01702-10
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