Efficacy of Calcium-EDTA as an Inhibitor for Metallo-β-Lactamase in a Mouse Model of Pseudomonas aeruginosa Pneumonia

In this study, we have evaluated the efficacy of calcium-EDTA (Ca-EDTA) as an inhibitor of bacterial metalloenzymes, such as metallo-β-lactamase (MBL) and other proteases, in a mouse model of Pseudomonas aeruginosa pneumonia. The simultaneous presence of Ca-EDTA (32 μg/ml) reduced the MICs of imipen...

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Main Authors: Aoki, Nobumasa, Ishii, Yoshikazu, Tateda, Kazuhiro, Saga, Tomoo, Kimura, Soichiro, Kikuchi, Yoshiaki, Kobayashi, Tetsuo, Tanabe, Yoshinari, Tsukada, Hiroki, Gejyo, Fumitake, Yamaguchi, Keizo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976153/
https://ncbi.nlm.nih.gov/pubmed/20713659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00511-10
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