Mutations in 23S rRNA at the Peptidyl Transferase Center and Their Relationship to Linezolid Binding and Cross-Resistance

The oxazolidinone antibiotic linezolid targets the peptidyl transferase center (PTC) on the bacterial ribosome. Thirteen single and four double 23S rRNA mutations were introduced into a Mycobacterium smegmatis strain with a single rRNA operon. Converting bacterial base identity by single mutations a...

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Detalhes bibliográficos
Main Authors: Long, Katherine S., Munck, Christian, Andersen, Theis M. B., Schaub, Maria A., Hobbie, Sven N., Böttger, Erik C., Vester, Birte
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976117/
https://ncbi.nlm.nih.gov/pubmed/20696869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00644-10
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