Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice

The postsynaptic muscle-specific kinase (MuSK) coordinates formation of the neuromuscular junction (NMJ) during embryonic development. Here we have studied the effects of MuSK autoantibodies upon the NMJ in adult mice. Daily injections of IgG from four MuSK autoantibody-positive myasthenia gravis pa...

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Detalhes bibliográficos
Main Authors: Cole, R N, Ghazanfari, N, Ngo, S T, Gervásio, O L, Reddel, S W, Phillips, W D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976017/
https://ncbi.nlm.nih.gov/pubmed/20603331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.190298
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