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NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced Inflammatory Osteolysis

BACKGROUND: Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone, and osteoblasts, which build bone. Disproportionate action of OCs is responsible for the bone loss associated with postmenopausal osteoporosis and rheumatoid arthritis. NF-κB inducing ki...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Chang, McCoy, Kathleen, Davis, Jennifer L., Schmidt-Supprian, Marc, Sasaki, Yoshiteru, Faccio, Roberta, Novack, Deborah Veis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975662/
https://ncbi.nlm.nih.gov/pubmed/21151480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015383
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