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Functional Rescue of a Misfolded Eukaryotic ATP-binding Cassette Transporter by Domain Replacement
ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP binding/hydrolysis with the transport of hydrophilic substrates across lipid barriers. Deletion of Phe-670 in the first nucleotide-binding domain (NBD1) of the yeast ABC transporter, Yor1p, perturbs interdomain as...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975245/ https://ncbi.nlm.nih.gov/pubmed/20843810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160523 |
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