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Activation of Human VPS4A by ESCRT-III Proteins Reveals Ability of Substrates to Relieve Enzyme Autoinhibition

VPS4 proteins are AAA(+) ATPases required to form multivesicular bodies, release viral particles, and complete cytokinesis. They act by disassembling ESCRT-III heteropolymers during or after their proposed function in membrane scission. Here we show that purified human VPS4A is essentially inactive...

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Sonraí Bibleagrafaíochta
Main Authors: Merrill, Samuel A., Hanson, Phyllis I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975166/
https://ncbi.nlm.nih.gov/pubmed/20805225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126318
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