Activation of Human VPS4A by ESCRT-III Proteins Reveals Ability of Substrates to Relieve Enzyme Autoinhibition

VPS4 proteins are AAA(+) ATPases required to form multivesicular bodies, release viral particles, and complete cytokinesis. They act by disassembling ESCRT-III heteropolymers during or after their proposed function in membrane scission. Here we show that purified human VPS4A is essentially inactive...

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Bibliographic Details
Main Authors: Merrill, Samuel A., Hanson, Phyllis I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975166/
https://ncbi.nlm.nih.gov/pubmed/20805225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126318
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