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Peptide-MHC Class II Complex Stability Governs CD4 T Cell Clonal Selection

The clonal composition of the T cell response can affect its ability to mediate infection control or to induce autoimmunity but the mechanisms regulating the responding TCR repertoire remain poorly defined. Here, we immunized mice with wild-type or mutated peptides displaying varying binding half-li...

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Detalhes bibliográficos
Main Authors: Baumgartner, Christina, Ferrante, Andrea, Nagaoka, Mika, Gorski, Jack, Malherbe, Laurent P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975033/
https://ncbi.nlm.nih.gov/pubmed/20007533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902107
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