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Vitreal Pharmacokinetics of Peptide-Transporter-Targeted Prodrugs of Ganciclovir in Conscious Animals

PURPOSE: To delineate the vitreal pharmacokinetics of dipeptide monoester prodrugs of ganciclovir (GCV) with conscious rabbit model using ocular microdialysis and to compare with published results from anesthetized model. METHODS: New Zealand albino male rabbit was selected as the animal model. Cons...

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Hlavní autoři: Janoria, Kumar G., Boddu, Sai H.S., Natesan, Subramanian, Mitra, Ashim K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974849/
https://ncbi.nlm.nih.gov/pubmed/20565313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2009.0123
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