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Automated electron-density sampling reveals widespread conformational polymorphism in proteins
Although proteins populate large structural ensembles, X-ray diffraction data are traditionally interpreted using a single model. To search for evidence of alternate conformers, we developed a program, Ringer, which systematically samples electron density around the dihedral angles of protein side c...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974833/ https://ncbi.nlm.nih.gov/pubmed/20499387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.423 |
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